Published by Elvira at November 5, 2013 There is one gene  – MTHFR –  that is getting a lot of attention right now, and for very good reason. MTHFR helps to drive some important metabolic pathways and it’s very common in our population. Approximately 5-12% of people are homozygous for the most common gene change in the MTHFR gene, 677C>T, making it an important starting point for healthcare.